abstract：:Use of cellular products for therapeutic purposes has predominantly been unregulated in Australia until recently. Transplant of haemopoietic progenitor cells (HPC) for bone marrow regeneration is now a routine treatment for many disorders with an established mechanism of facility accreditation. However, other cellular...

journal_title：Pathology

authors： Trickett AE,Wall DM

更新日期：2011-10-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a non-homogeneous population of plastic-adherent cells which were initially isolated from post-natal bone marrow. They have the capacity to differentiate to multiple mesodermal lineages including bone, cartilage and adipose tissue. In stringent culture conditions, MSCs can also be ...

journal_title：Pathology

authors： Larsen S,Lewis ID

更新日期：2011-10-01 00:00:00

abstract：AIMS:Serum cobalamin (cbl, vitamin B(12)) tests are routinely ordered for investigating conditions potentially amenable to cbl supplementation. This study aimed to systematically assess the evidence of diagnostic accuracy for serum cbl tests across patient subgroups. METHODS:Seven medical databases were searched (1990...

journal_title：Pathology

authors： Willis CD,Elshaug AG,Milverton JL,Watt AM,Metz MP,Hiller JE,ASTUTE Health Study Group.

更新日期：2011-08-01 00:00:00

abstract：:In the 20 years that cardiac troponin testing has been available in clinical laboratories, the biomarker has revolutionised testing of patients with acute coronary syndromes. Cardiac troponin I and T testing has become the cornerstone for diagnosis of myocardial infarction and is useful for risk assessment and managem...

journal_title：Pathology

authors： Christenson RH,Phillips D

更新日期：2011-04-01 00:00:00

abstract：:The sections in the following review cover six main neurodegenerative diseases. The first article on Alzheimer's disease (AD) outlines the major evidence available to date that links Aβ-amyloid peptide as a proximal cause of AD. The article also highlights how an initial finding of the protein content of the amyloid p...

journal_title：Pathology

authors： Masters CL,Kril JJ,Halliday GM,Pamphlett R,Collins S,Hill AF,McLean C

更新日期：2011-02-01 00:00:00

abstract：AIMS:INI1 expression and its correlation with MGMT gene promoter methylation status and follow-up was investigated in 77 surgically removed glioblastomas then treated with radiotherapy (RT) or RT plus temozolomide (TMZ). METHODS:INI1 was determined by immunohistochemistry and MGMT by methylation-specific PCR. RESULTS...

journal_title：Pathology

authors： Zunarelli E,Bigiani N,Sartori G,Migaldi M,Sgambato A,Maiorana A

更新日期：2011-01-01 00:00:00

abstract：AIM:Performance measures for Australian laboratories reporting cervical cytology are a set of quantifiable measures relating to the profile and accuracy of reporting. This study reviews aggregate data collected over the ten years in which participation in the performance measures has been mandatory. METHODS:Laboratori...

journal_title：Pathology

authors： Shield PW,Finnimore J,Cummings M,Wright RG

更新日期：2010-12-01 00:00:00

abstract：:We present the clinicopathological features of eight cases of large cell undifferentiated bladder carcinoma not otherwise specified (LCUBC). LCUBC was characterised by sheets of large polygonal or round cells with moderate to abundant cytoplasm and distinct cell borders. The LCUBC component varied from 90 to 100% of t...

journal_title：Pathology

authors： Lopez-Beltran A,Cheng L,Comperat E,Rouprêt M,Blanca A,Menendez CL,Montironi R

更新日期：2010-06-01 00:00:00

abstract：AIM:We investigated the role of renal sympathetic innervation in the deterioration of renal haemodynamic and excretory functions during the early post-ischaemic phase of renal ischaemia/reperfusion injury. METHODS:Anaesthetised male Sprague-Dawley rats were subjected to unilateral renal ischaemia by clamping the left ...

journal_title：Pathology

authors： Salman IM,Ameer OZ,Sattar MA,Abdullah NA,Yam MF,Najim HS,Khan AH,Johns EJ

更新日期：2010-04-01 00:00:00

abstract：:The cancer stem cell hypothesis suggests that malignant tumours may arise from a limited number of specialised cells possessing the key 'stem' properties of self-renewal and the ability to produce differentiated progeny. Such cells purportedly constitute a small fraction of most tumours but have greater potential to p...

journal_title：Pathology

authors： Hemmings C

更新日期：2010-02-01 00:00:00

abstract：AIMS:Activation of nuclear factor-kappa B (NF-kappaB) signalling is considered a crucial mechanism in the development of cancers. Caspase-associated recruitment domain 6 (CARD6) is a protein that activates NF-kappaB signalling evoked by RIP1, RIP2, Bcl-10 and MEKK. In this study, we analysed tissue expression of CARD6 ...

journal_title：Pathology

authors： Kim SS,Ahn CH,Kang MR,Kim YR,Kim HS,Yoo NJ,Lee SH

更新日期：2010-01-01 00:00:00

abstract：AIMS:Recent study indicates that the binding of caveolin-1 (CAV1), the essential constituent of caveolae, to endothelial nitric oxide synthase (eNOS) prevents nitric oxide (NO) production in cirrhotic human liver. However, their interplay in hepatocellular carcinoma (HCC) remains undetermined. METHODS:Paraffin-embedde...

journal_title：Pathology

authors： Yang SF,Yang JY,Huang CH,Wang SN,Lu CP,Tsai CJ,Chai CY,Yeh YT

更新日期：2010-01-01 00:00:00

abstract：AIMS:This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC). METHODS:Loss of heterozygosity (LOH) and BRAF(V600E) mutation status were analysed in a total of 55 individual tumour foci from 18 cas...

journal_title：Pathology

authors： Jovanovic L,Delahunt B,McIver B,Eberhardt NL,Bhattacharya A,Lea R,Grebe SK

更新日期：2010-01-01 00:00:00

abstract：AIM:To compare the relative diagnostic efficacy of several different tests used to establish a diagnosis of phaeochromocytoma, in patients with a proven diagnosis of phaeochromocytoma, and in hospital patients with significant disease of other types. METHODS:We prospectively compared biochemical markers of catecholami...

journal_title：Pathology

authors： Hickman PE,Leong M,Chang J,Wilson SR,McWhinney B

更新日期：2009-02-01 00:00:00

abstract：AIM:Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism. It is regarded as a factor regulating the uptake of dietary iron and its mobilisation from macrophages and hepatic stores. It is considered as a mediator of anaemia of inflammation. The aim of this study was to assess whether s...

journal_title：Pathology

authors： Jayaranee S,Sthaneshwar P,Sokkalingam S

更新日期：2009-02-01 00:00:00

abstract：AIMS AND METHODS:During colorectal carcinogenesis, transforming growth factor beta 1 (TGF-beta1) undergoes a functional change from suppression of cancer cell proliferation to inhibition of T cell mediated anti-cancer immunity. We aimed to evaluate relations among TGF-beta1 and cancer cell survival factors hypoxia indu...

journal_title：Pathology

authors： Sulkowska M,Wincewicz A,Sulkowski S,Koda M,Kanczuga-Koda L

更新日期：2009-01-01 00:00:00

abstract：:Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...

journal_title：Pathology

authors： Foschini MP,Eusebi V

更新日期：2009-01-01 00:00:00

abstract：AIMS:Nuclear factor-kappa B (NF-kappaB) activation has been recognised as an important mechanism in the development of cancers. However, expression status of NF-kappaB-related proteins in oesophageal squamous cell carcinoma (ESCC) tissues is largely unknown. In this study, we analysed expressions of NF-kappaB members (...

journal_title：Pathology

authors： Kang MR,Kim MS,Kim SS,Ahn CH,Yoo NJ,Lee SH

更新日期：2009-01-01 00:00:00

abstract：AIMS:Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, some studies have suggested that SIRT1 could be over-expressed in breast, prostate and colon cancers and up-regulated SIRT1 inactivates p53 by deacetylation. Therefore, we investigated the prevalence and the prognostic impact ...

journal_title：Pathology

authors： Jang KY,Kim KS,Hwang SH,Kwon KS,Kim KR,Park HS,Park BH,Chung MJ,Kang MJ,Lee DG,Moon WS

更新日期：2009-01-01 00:00:00

abstract：AIM:To determine whether whole of gestation exposure of fetal mouse brain to mobile telephone radiofrequency fields produces a stress response detectable by induction of heat shock proteins (HSPs). METHODS:Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exp...

journal_title：Pathology

authors： Finnie JW,Chidlow G,Blumbergs PC,Manavis J,Cai Z

更新日期：2009-01-01 00:00:00

abstract：AIMS:Only a small number of mesenchymal tumours have been previously evaluated for hTERT expression. We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours. METHODS:Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using ...

journal_title：Pathology

authors： Patel RM,Folpe AL

更新日期：2009-01-01 00:00:00

abstract：AIM:Considering the fact that histology and its grading systems are accepted gold standards in diagnosis of diverse clinical disorders, assessing the accuracy and reliability of this method of diagnosis is of utmost importance. Thus, this study was performed to measure the agreement values between four independent hist...

journal_title：Pathology

authors： Talebkhan Y,Mohammadi M,Rakhshani N,Abdirad A,Fayaz Moughadam K,Fereidooni F

更新日期：2009-01-01 00:00:00

abstract：AIMS:To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. M...

journal_title：Pathology

authors： Wu X,Dagar V,Algar E,Muscat A,Bandopadhayay P,Ashley D,Wo Chow C

更新日期：2008-12-01 00:00:00

abstract：AIMS:There are many variants of papillary carcinoma, and some of these variants have been reported to show biological behaviours differing from that of conventional papillary carcinoma. In this study, we present our experience regarding the prevalence and prognoses of these variants of papillary carcinoma. METHODS:H&E...

journal_title：Pathology

authors： Ito Y,Hirokawa M,Uruno T,Kihara M,Higashiyama T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

更新日期：2008-10-01 00:00:00

abstract：AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...

journal_title：Pathology

authors： Kim SY,Oh YL,Kim KM,Jeong EG,Kim MS,Yoo NJ,Lee SH

更新日期：2008-10-01 00:00:00

abstract：AIMS:CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours. We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties. METHODS:We ev...

journal_title：Pathology

authors： Fritzsche FR,Wassermann K,Rabien A,Schicktanz H,Dankof A,Loening SA,Dietel M,Jung K,Kristiansen G

更新日期：2008-08-01 00:00:00

abstract：AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...

journal_title：Pathology

authors： Gong L,Zhang W,Su Q

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Detection of the V600E hotspot mutation in BRAF oncogene is extremely useful for the screening of hereditary non-polyposis colorectal cancer (Lynch's syndrome) and for the prediction of sensitivity to MEK inhibitors. Here we describe a method for detecting this mutation based upon pyrosequencing technology...

journal_title：Pathology

authors： Tan YH,Liu Y,Eu KW,Ang PW,Li WQ,Salto-Tellez M,Iacopetta B,Soong R

更新日期：2008-04-01 00:00:00

abstract：:Birth defects of the brain result from malformation and disruptions. They remain an important cause of childhood morbidity and mortality. Effective treatments are scarce and prevention strategies limited. As aetiological screening is costly and uncertain, genetic counselling remains empirical in most cases. A patholog...

journal_title：Pathology

authors： Encha-Razavi F,Gonzalès M,Laquerrière A,Martinovic J,Sinico M,Allias F,Bonnière M,Esculpavit C,Gerard M,Attié-Bitach T,Vekemans M

更新日期：2008-02-01 00:00:00

abstract：AIM:Gasdermin-like (GSDML) is a novel member of the cancer associated gasdermin-domain containing (GSDMDC) protein family. The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML. METHODS:GSDML gene transcript...

journal_title：Pathology

authors： Carl-McGrath S,Schneider-Stock R,Ebert M,Röcken C

更新日期：2008-01-01 00:00:00

abstract：AIMS:To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types. METHODS:Information was extracted from the Registry database using 58 selected fields. RESULTS:During the 25 year period, 8...

journal_title：Pathology

authors： Blackwell JB,Curnow MN

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Ethanol is teratogenic, interferes with folic acid and is extensively used by young women. Our objective was to determine the effects of ethanol and/or folate deficiency on mouse fetuses. METHOD:In Experiment 1, pregnant mice receiving a commercial diet were divided into three groups: control (C), low eth...

journal_title：Pathology

authors： Gutierrez CM,Ribeiro CN,de Lima GA,Yanaguita MY,Peres LC

更新日期：2007-10-01 00:00:00

abstract：AIM:Both hypoxia inducible factor 1 (HIF-1) and basic fibroblast growth factor (bFGF) play important roles in tumour angiogenesis. This study was designed to clarify the cooperative effect of these two mediators in induction of vascular endothelial cell growth factor (VEGF) release from breast cancer and probe possible...

journal_title：Pathology

authors： Shi YH,Bingle L,Gong LH,Wang YX,Corke KP,Fang WG

更新日期：2007-08-01 00:00:00

abstract：AIMS:Whereas most caspases play roles in apoptosis and/or inflammation, caspase-14 plays a main role in epithelial differentiation. In cancers, expression of caspase-14 is frequently altered and is associated with some clinicopathological characteristics, suggesting caspase-14 might contribute to the pathogenesis of ca...

journal_title：Pathology

authors： Yoo NJ,Soung YH,Lee SH,Jeong EG,Lee SH

更新日期：2007-06-01 00:00:00

abstract：:Histopathologists are encountering intra-lobular epithelial proliferations more frequently in core biopsies taken from lesions identified in mammographic breast screening programmes. In particular, columnar cell lesions are increasingly being seen in core biopsies taken for the histological assessment of mammographica...

journal_title：Pathology

authors： Pinder SE,Provenzano E,Reis-Filho JS

更新日期：2007-04-01 00:00:00

abstract：:Since its first description in the early part of the twentieth century, struma ovarii has elicited considerable interest because of its many unique features; however, at present a number of aspects remain enigmatic. Although the typical presentation is that of a pelvic mass, unusual clinical manifestations such as hyp...

journal_title：Pathology

authors： Roth LM,Talerman A

更新日期：2007-02-01 00:00:00

abstract：:The careers and contributions of some of those who have played a major role in the development of knowledge concerning gynaecological pathology are summarised. The emphasis is on workers of prior times beginning with those of the German-speaking school: Carl Ruge, Felix Marchand, Hermann Pfannenstiel, Oskar Frankl, Wa...

journal_title：Pathology

authors： Young RH

更新日期：2007-02-01 00:00:00

abstract：AIMS:It is currently accepted that primary ovarian tumours rarely, if ever, give rise to mucinous ascites/pseudomyxoma peritonei (PMP) which most commonly results from the intra-abdominal spread of an appendiceal mucinous neoplasm. However, primary ovarian mucinous tumours of appendiceal type arising within mature cyst...

journal_title：Pathology

authors： Stewart CJ,Tsukamoto T,Cooke B,Leung YC,Hammond IG

更新日期：2006-12-01 00:00:00

abstract：AIMS:Matrix metalloproteinases (MMPs) have various functions that play roles in carcinoma development. In this study, we investigated the expression of two representative MMPs, MMP-7 and MMP-11, in papillary thyroid carcinomas. METHODS:We immunohistochemically investigated the expression of these MMPs in 196 cases of ...

journal_title：Pathology

authors： Ito Y,Yoshida H,Kakudo K,Nakamura Y,Kuma K,Miyauchi A

更新日期：2006-10-01 00:00:00

abstract：AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...

journal_title：Pathology

authors： Selvarajan S,Tan SY,Sii LH,Tan PH

更新日期：2006-08-01 00:00:00